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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACO1
All Species:
34.85
Human Site:
Y196
Identified Species:
54.76
UniProt:
P21399
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P21399
NP_002188.1
889
98399
Y196
V
F
D
Q
D
G
Y
Y
Y
P
D
S
L
V
G
Chimpanzee
Pan troglodytes
XP_001155934
889
98362
Y196
V
F
D
Q
D
G
Y
Y
Y
P
D
S
L
V
G
Rhesus Macaque
Macaca mulatta
XP_001103675
889
98487
Y196
V
F
D
Q
D
G
Y
Y
Y
P
D
S
L
V
G
Dog
Lupus familis
XP_538698
889
98299
Y196
V
F
D
H
D
G
Y
Y
Y
P
D
S
L
V
G
Cat
Felis silvestris
Mouse
Mus musculus
P28271
889
98160
Y196
V
F
D
Q
D
G
C
Y
Y
P
D
S
L
V
G
Rat
Rattus norvegicus
Q63270
889
98109
Y196
V
F
D
Q
D
G
C
Y
Y
P
D
S
L
V
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509375
889
98624
Y196
V
F
D
Q
N
E
Y
Y
Y
P
D
S
L
V
G
Chicken
Gallus gallus
Q90875
889
98055
Y196
V
M
D
Q
D
G
Y
Y
Y
P
D
S
V
V
G
Frog
Xenopus laevis
Q6NTP2
955
104418
I265
V
M
E
E
K
G
C
I
Y
P
D
S
V
L
G
Zebra Danio
Brachydanio rerio
NP_001030155
890
98920
Y196
V
F
D
Q
D
G
F
Y
Y
P
D
S
L
V
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524303
899
98560
D200
V
F
E
N
D
A
T
D
G
S
K
I
L
Y
P
Honey Bee
Apis mellifera
XP_392993
890
98796
L198
V
F
D
T
N
G
I
L
Y
P
D
S
V
V
G
Nematode Worm
Caenorhab. elegans
Q23500
887
96642
V194
V
F
V
G
K
D
G
V
L
Y
P
D
S
V
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SIB9
990
108183
L292
V
F
N
T
K
G
L
L
Y
P
D
S
V
V
G
Baker's Yeast
Sacchar. cerevisiae
P19414
778
85350
G131
H
L
I
Q
A
Q
V
G
G
E
K
D
L
K
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
98.9
93.2
N.A.
93.4
92.9
N.A.
90.4
87.5
55.7
82.2
N.A.
67.9
69.4
62.9
N.A.
Protein Similarity:
100
100
99.5
96.9
N.A.
97.7
97.7
N.A.
95.1
93.8
72.2
92
N.A.
82.1
82.5
77.1
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
86.6
86.6
46.6
93.3
N.A.
26.6
66.6
20
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
93.3
93.3
73.3
100
N.A.
33.3
80
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
55.6
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
69.6
43.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
7
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
20
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
67
0
60
7
0
7
0
0
80
14
0
0
0
% D
% Glu:
0
0
14
7
0
7
0
0
0
7
0
0
0
0
0
% E
% Phe:
0
80
0
0
0
0
7
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
7
0
74
7
7
14
0
0
0
0
0
80
% G
% His:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
0
0
0
7
7
0
0
0
7
0
0
0
% I
% Lys:
0
0
0
0
20
0
0
0
0
0
14
0
0
7
0
% K
% Leu:
0
7
0
0
0
0
7
14
7
0
0
0
67
7
0
% L
% Met:
0
14
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
7
14
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
80
7
0
0
0
7
% P
% Gln:
0
0
0
60
0
7
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% R
% Ser:
0
0
0
0
0
0
0
0
0
7
0
80
7
0
0
% S
% Thr:
0
0
0
14
0
0
7
0
0
0
0
0
0
0
0
% T
% Val:
94
0
7
0
0
0
7
7
0
0
0
0
27
80
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
40
60
80
7
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _